Current Research
The types of research currently undertaken at the Trust are varied, from complex clinical trials, qualitative health service research, registries, post-marketing surveillance to trainee doctors and students doing low risk, own account studies. Much of this research has been adopted by the National Institute of Health Research (approx 90%) with a small number of commercial/pharmaceutical (independent of NIHR) making up the rest.
Cancer Research
Breast
ROSCO: Response to Optimal Selection of neo-adjuvant Chemotherapy in Operable breast cancer: A randomised phase III, stratified biomarker trial of neoadjuvant 5-Fluorouracil, Epirubicin and Cyclophosphamide vs Docetaxel and Cyclophphamide chemotherapy.
Principal Investigator (PI): Dr Jo Dent
IMPASSION: A Phase III multicentre, randomised open-label study comparing Atezolizumab in combination with adjuvant anthracycline/taxane-based chemotherapy versus chemotherapy alone in patients with operable triple-negative breast cancer.
Principal Investigator (PI): Dr Jo Dent
ATNEC: A randomised trial investigating the requirement for axillary treatment, after chemotherapy, for patients with early stage breast cancer.
Principal Investigator (PI): Dr Werbena Hamilton-Burke
MARECA: National study of management of breast cancer locoregional recurrence and oncological outcome.
Principal Investigator (PI): Dr Richard Frame
Colorectal
YCRBCIP: Yorkshire Cancer Research Bowel Cancer Improvement Programme. Does intensive multidisciplinary team intervention improve bowel cancer outcomes in Yorkshire?
Principal Investigator (PI): Ms Paula Pickersgill
OnCoRe: Oncological Outcomes after Clinical Complete Response (cCR) in patients with rectal cancer.
Principal Investigator (PI): Miss Tamsyn Grey
FOxTROT2: Personalising neo-adjuvant Chemotherapy in Locally advanced but operable colon cancer. A randomised trial programme.
Principal Investigator (PI): Dr Sam Turnbull
ARIEL: A biomarker enrichment trial of anti-EGFR agents in patients with advanced colorectal cancer (aCRC) with wild-type RAS and right primary tumour location (right-PTL).
Principal Investigator (PI): Dr Sam Turnbull
Pancreatic
ACTICCA-1: Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma.
Principal Investigator (PI): Dr Emma Rathbone
PRECISION-Panc: Advancing personalised medicine treatment strategies for pancreatic cancer.
Principal Investigator (PI): Dr Emma Rathbone
PRIMUS 001: An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation.
Principal Investigator (PI): Dr Emma Rathbone
UK-EDI: UK Early Detection Initiative for Pancreatic Cancer.
Principal Investigator (PI): Dr Sabari Haridass
Haematology
CML Registry: The study programme to investigate modern trends in Chronic Myeloid Leukemia (CML)
Principal Investigator (PI): Dr Kate Rothwell
FLAIR: This is a phase III, multicentre, randomised, controlled, open, parallel group trial in patients with previously untreated CLL.
Principal Investigator (PI): Dr Kate Rothwell
MYELOMA XIV (FITNESS): A phase III trial to compare standard and frailty-adjusted induction therapy with ixazomib, lenalidomide and dexamethasone (IRD) and maintenance lenalidomide (R) to lenalidomide plus ixazomib (R+I)
Principal Investigator (PI): Dr Sylvia Feyler
RADAR (UK-MRA Myeloma XV): Risk-Adapted therapy Directed According to Response comparing treatment escalation and de-escalation strategies in newly diagnosed patients with multiple myeloma (NDMM) suitable for stem cell transplant (TE).
Principal Investigator (PI): Dr Sylvia Feyler
Lung
SKYSCRAPER-03: A Phase III, open label, randomized study of Atezolizumab and Tiragolumab compared with Durvalumab in patients with locally advanced unrespectable stage III non-small cell lung cancer who have not progressed after concurrent platinum-based chemoradiation.
Principal Investigator (PI): Dr Emma Rathbone
NIMBLE: Nodule Immunophenotyping biomarker for lung cancer early diagnosis study.
Principal Investigator (PI): Dr Steven Thomas
Prostate
STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
Principal Investigator (PI): Dr Uschi Hofmann
Other Cancers
ICI Genetics: Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity. Participants recruited from all forms of cancer.
Principal Investigator (PI): Dr Emma Rathbone
Other Specialty Research
Cardiovasular
EVAREST: The use of blood biomarkers, including Extracellular Vesicles, to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram.
Principal Investigator (PI): Dr Jeremy Butts
EASY-AS: A Randomised Controlled Trial of Early valve replacement in severe ASYmptomatic Aortic Stenosis.
Principal Investigator (PI): Dr Hossam Elmahy
Dermatology
BADBIR: British Association of Dermatologists Biologics and Immunomodulators Register
Principal Investigator (PI): Dr Corrine Jakeman
Endocrinology
IONIS CORE: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia.
Principal Investigator (PI): Dr Sabari Haridass
Gastrointestinal
PRED 4: Predicting serious drug side effects in gastroenterology.
Principal Investigator (PI): Dr Sunil Sonwalker
IBD BioResource: The UK Inflammatory Bowel Disease Bioresource: Progressing from Genetics to Function and Clinical Translation in Crohn's Disease & Ulcerative Colitis.
Principal Investigator (PI): Dr Sunil Sonwalker
GONDOMAR: Goals, Needs and outcome Determinants Of Multimodal therapy in Perianal Crohn's fistula.
Principal Investigator (PI): Dr Mohammed Allah-Ditta
Health Service & Delivery Research
FALLS: Practices of falls risk assessment and prevention in acute hospital settings: A realist investigation.
Principal Investigator (PI): Dr Abhijit Chakraborty
PQIP Perioperative Quality Improvement Programme: A patient study improving perioperative care through the use of quality data. Gathering and analysis of patient data using the PQIP Database.
Principal Investigator (PI): Dr Alex Spyridoulias
Physician Associate post-qualification Training in UK hospitals: Experiences of newly qualified PAs and their employers.
Principal Investigator (PI): Dr Sarah Howarth (PhD)
Haematology
MDS Registry for newly diagnosed patients: A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes
Principal Investigator (PI): Dr Kate Rothwell
MIRTHRIDATE: A phase III, randomised, open-label, Multicenter International Trial comparing ruxolitinib with either HydRoxycarbamIDe or interferon Alpha as first line ThErapy for high risk polycythemia vera.
Principal Investigator (PI): Dr Sylvia Feyler
Hepatology
PBC Genetics Study: Investigation of the Genetic and Molecular Pathogenesis of Primary Biliary Cirrhosis.
rincipal Investigator (PI): Dr Susan Jones
NAFLD BioResource: A Research Study to Characterise Novel Clinical and Genetic Phenotypes, and Understand the Natural History of Non-Alcoholic Fatty Liver Disease (NAFLD).
Principal Investigator (PI): Dr Puneet Chhabra
ALLHEAL: Alcohol and Liver Health.
Principal Investigator (PI): Dr Swastik Agrawal
Infection
DexEnceph: A pragmatic, randomised, controlled, observer blind trial comparing clinical outcomes in adults who receive dexamethasone alongside standard treatment versus standard treatment alone for Herpes Simplex Virus encephalitis.
Principal Investigator (PI): Dr Rangaprasad Karadi
Maternity
CRAFT: CeRclage After Full dilaTation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies.
Principal Investigator (PI): Dr Tahira Naeem
OASI2: Evaluation of strategies for care bundle implentation.
Principal Investigator (PI): Midwife Rachel Clifford & Dr Ranadeb Acharyya
TTTS Registry: A physician-run Multiple Pregnancy Registry in collaboration with the Twin & Multiple Births Association (TAMBA), designed to serve the interests of patients while overcoming challenges of sharing data over great distances while protecting patient privacy.
Principal Investigator (PI): Dr Fifydani Shamsudin
CAPE: Calcium Supplementation for Prevention of Pre-eclampsia in High Risk Women.
Principal Investigator (PI): Dr Fifydani Shamsudin
Musculoskeletal
BSRBR: Toxicity from biologic therapy
Principal Investigator (PI): Dr Omer Sharif
INSPIRE: INjectable treatments for patients with Shoulder Pain: a prospective observatIonal study to deteRmine Efficacy: Does injection treatment improve 26-week shoulder symptoms? A multi-centre, observational, prospective study.
Principal Investigator (PI): Dr Rajesh Menon
Adherence to Shoulder rehab: Exploration of barriers and enablers to shoulder rehabilitation exercises.
Physiotherapist collaborators: Tash Maher & Laura Hedley
Neurological
Validation of translational biomarkers of neuropathic pain: RECRUITMENT SUSPENDED The Identification and validation of translational biomarkers of Neuropathic Pain. A matched cohort study investigating biomarkers in several sub-group populations of Neuropathic Pain.
Principal Investigator (PI): Dr Rajesh Menon
MIDI: Deep Learning for Identification of Abnormalities on Head MRI.
Principal Investigator (PI): Mrs Georgina Turner
MiNDToolkit Feasibility Study: Practical Management of Cognitive and Behavioural Impairment in Motor Neurone Disease.
Prinicpal Investigator (PI): Beth Macdonald
Ophthalmology
GRIP Glaucoma Risk Prediction in ocular hypertension: a cohort study using electronic medical records to validate a risk predictor and determine the cost-effectiveness of different monitoring schemes according to risk of conversion to glaucoma.
Principal Investigator (PI): Dr Omar Rafiq
SEARCH: Visual scanning training for hemianopia.
Principal Investigator (PI): Rachael Calvey
Patient-practitioner communication in AMD: Investigating the delivery and impact of patient-practitioner communication in modifying lifestyle of people with Age-Related Macular Degeneration.
Principal Investigator (PI): Dr Indra Dias
ATHENA: Optical Coherence Tomography Angiography for the detection of Neovascular Age-related Macular Degeneration: a Comprehensive Diagnostic Accuracy Study.
Principal Investigator (PI): Dr Indra Dias
Other Speciality
Physical activity levels of FH patients: Physical activity levels of Familial Hypercholesterolaemia patients and do they meet the current NICE recommendations.
Principal Investigator (PI): Jillian Webster
Paediatric
BIOJUME: Biology of Juvenile Myoclonic Epilepsy
Principal Investigator (PI): Dr Matthew Taylor
Cleft Collective: Cohort Studies - a large DNA backed prospective resource for the study of the genetic and environmental determinants of cleft lip and/or palate and the long term outcomes in children with cleft lip and/or palate.
Principal Investigator (PI): Rebecca Leon
Cystic Fibrosis: Cystic Fibrosis Registry.
Principal Investigator (PI): Dr Amal Elnour
Rolandic Epilepsy Genomewide Association International Study (REGAIN): The study’s goal is to find the genetic basis for susceptibility to seizures and associated comorbidities for RE (Rolandic Epilepsy) using genomewide association approaches.
Principal Investigator (PI): Dr Matthew Taylor
AZTEC-2: Long term follow-up of Azithromycin Therapy for Chronic Lung Disease of Prematurity.
Prinicipal Investigator (PI): Dr Gill Sharpe
CF START: The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF
Principal Investigator (PI): Dr Abdul Mattara
FEED1 - Fluids Exclusively Enteral from Day 1: A randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30-33 weeks gestational age).
Principal Investigator (PI): Dr Abdul Mattara
Renal & Urogenital
RADAR: National Studies of Rare Kidney Diseases
Principal Investigator (PI): Dr Rahul Vundru
Respiratory
EMBARC: European Bronchiectasis Registry
Principal Investigator (PI): Dr Rehan Naseer
BTS Registry: RECRUITMENT SUSPENDED Obesity related severe asthma – relationship between body mass index and symptoms, healthcare utilisation, demographics, medications, blood test results and lung function.
Principal Investigator (PI): Dr Rehan Naseer
TIPAL: The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole: a randomised placebo-controlled multi-centre clinical trial.
Principal Investigator (PI): Dr Anneka Biswas
TB-DILI: Reintroduction of anti-tuberculosis therapy following drug-induced liver injury: a randomised controlled trial.
Principal Investigator (PI): Dr Nicholas Scriven
Sexual Health
DEVA: Dequalinium versus usual care antibiotics for the treatment of bacterial vaginosis. A multicentre randomised, open label, non-inferiority trial.
Principal Investigator (PI): Dr Emma Street
Positive Voices - National Survey of People with HIV: Development and Implementation of Positive Voices: the National Survey of People Living with HIV.
Principal Investigator (PI): Dr Emma Street
Stroke
OPTIMAS: A randomised, controlled trial considering Optimal Timing of Anticoagulation after an acute ischaemic stroke.
Principal Investigator (PI): Dr Manohar Kini
ENRICH-AF: EdoxabaN foR IntraCranial Haemorrhage survivors with atrial fibrillation.
Principal Investigator (PI): Dr Pratap Rana
PREPARE: imPRoving End of life care Practice in stroke cAREon.
Principal Investigator (PI): Ashleigh Reeves
Surgical
SUNFLOWER: A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones.
Principal Investigator (PI): Mr Arin Saha
ROSSINI 2: Reduction Of Surgical Site Infection using several Novel Interventions.
Principal Investigator (PI): Dr Muneer Junejo
PQIP Perioperative Quality Improvement Programme: A patient study improving perioperative care through the use of quality data. Gathering and analysis of patient data using the PQIP Database.
Principal Investigator (PI): Dr Alex Spyridoulias
Trauma & Orthopaedics
PROFHER2: A three-arm randomised controlled trial to assess the effectiveness and cost-effectiveness of reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical care for acute three and four part fractures of the proximal humerus in patients over 65yrs of age - Proximal Fracture Of the Humerus: Evaluation by Randomisation trial No. 2.
Principal Investigator (PI): Mr Neil Pennington
SOFFT: Suture fixation versus tension band wiring for simple olecranon fracture fixation: a multi-centre randomised controlled trial (Simple Olecranon Fracture Fixation Trial – SOFFT).
Principal Investigator (PI): Mr Neil Pennington
