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Current Research

The types of research currently undertaken at the Trust are varied, from complex clinical trials, qualitative health service research, registries, post-marketing surveillance to trainee doctors and students doing low risk, own account studies. Much of this research has been adopted by the National Institute of Health Research (approx 90%) with a small number of commercial/pharmaceutical (independent of NIHR) making up the rest.

Due to the current COVID-19 outbreak Calderdale & Huddersfield NHS Foundation Trust have suspended recruitment on a number of their studies. 

Please view the sections below giving status for each research study at Calderdale & Huddersfield Foundation Trust.

Cancer Research

Breast

ROSCO: Response to Optimal Selection of neo-adjuvant Chemotherapy in Operable breast cancer: A randomised phase III, stratified biomarker trial of neo­adjuvant 5-Fluorouracil, Epirubicin and Cyclophosphamide vs Docetaxel and Cyclophphamide chemotherapy.

Principal Investigator (PI): Dr Jo Dent

IMPASSION: A Phase III multicentre, randomised open-label study comparing Atezolizumab in combination with adjuvant anthracycline/taxane-based chemotherapy versus chemotherapy alone in patients with operable triple-negative breast cancer.

Principal Investigator (PI): Dr Jo Dent

ATNEC: A randomised trial investigating the requirement for axillary treatment, after chemotherapy, for patients with early stage breast cancer.

Principal Investigator (PI): Dr Werbena Hamilton-Burke

MARECA: National study of management of breast cancer locoregional recurrence and oncological outcome.

Principal Investigator (PI): Dr Richard Frame 

NEO21-RS Study:  A phase II randomised study of the cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with oestrogen suppression therapy versus oestrogen suppression therapy alone as neoadjuvant therapy in ER-positive intermediate recurrence score primary breast cancer.

Principal Investigator (PI): Dr Jo Dent  

Colorectal

YCRBCIP: Yorkshire Cancer Research Bowel Cancer Improvement Programme. Does intensive multidisciplinary team intervention improve bowel cancer outcomes in Yorkshire?

Principal Investigator (PI): Ms Paula Pickersgill 

OnCoRe: Oncological Outcomes after Clinical Complete Response (cCR) in patients with rectal cancer.

Principal Investigator (PI): Miss Tamsyn Grey

FOxTROT2: Personalising neo-adjuvant Chemotherapy in Locally advanced but operable colon cancer. A randomised trial programme.

Principal Investigator (PI): Dr Sam Turnbull 

Emergency Care

SHED: Subarachnoid Haemorrhage in the Emergency Department.

Principal Investigator (PI): Dr Huw Masson

Gastrointestinal

ACTICCA-1: Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma. 

Principal Investigator (PI): Dr Emma Rathbone

PRECISION-Panc: Advancing personalised medicine treatment strategies for pancreatic cancer.

Principal Investigator (PI): Dr Emma Rathbone

PRIMUS 001: An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation.

Principal Investigator (PI): Dr Emma Rathbone

IBD BioResource: The Inflammatory Bowel Disease BioResource: Progressing from Genetics to Function and Clinical Translation in Crohn's Disease & Ulcerative Colitis.

Principal Investigator (PI): Dr Sun Sonwalker

 

Gynaecological

The BIG BABY Trial: Induction of labour for predicted macrosomia.

Principal Investigator (PI): Dr Julie Goddard

TTTS Registry: A physician-run Multiple Pregnancy Registry in collaboration with the Twin & Multiple Births Association (TAMBA), designed to serve the interests of patients while overcoming challenges of sharing data over great distances while protecting patient privacy.

Principal Investigator (PI): Dr Fifydani Shamsudin

AZTEC: Azithromycin Therapy for Chronic Lung Disease of Prematurity.

Principal Investigator (PI): Dr Gill Sharpe

AZTEC-2: Long term follow-up of Azithromycin Therapy for Chronic Lung Disease of Prematurity.

Prinicipal Investigator (PI): Dr Gill Sharpe

OASI2: Evaluation of strategies for care bundle implentation. 

Principal Investigator (PI): Midwife Rachel Clifford & Dr Ranadeb Acharyya

The CERM Trial: Chronic Endometritis and Recurrent Miscarriage.

Principal Investigator (PI): Dr Aris Makis 

Haematology

CML Registry: The study programme to investigate modern trends in Chronic Myeloid Leukemia (CML)

Principal Investigator (PI): Dr Kate Rothwell

FLAIR: This is a phase III, multicentre, randomised, controlled, open, parallel group trial in patients with previously untreated CLL.

Principal Investigator (PI): Dr Kate Rothwell

MDS Registry for newly diagnosed patients: A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes

Principal Investigator (PI): Dr Kate Rothwell

Myeloma XII (ACCoRd trial) Version 1.0: A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT Consolidation and maintenance strategy in patients with Relapsed multiple myeloma.

Principal Investigator (PI): Dr Sylvia Feyler

MYELOMA XIV (FITNESS): A phase III trial to compare standard and frailty-adjusted induction therapy with ixazomib, lenalidomide and dexamethasone (IRD) and maintenance lenalidomide (R) to lenalidomide plus ixazomib (R+I)

Principal Investigator (PI): Dr Sylvia Feyler

RADAR (UK-MRA Myeloma XV): Risk-Adapted therapy Directed According to Response comparing treatment escalation and de-escalation strategies in newly diagnosed patients with multiple myeloma (NDMM) suitable for stem cell transplant (TE).

Principal Investigator (PI): Dr Sylvia Feyler

MIRTHRIDATE: A phase III, randomised, open-label, Multicenter International Trial comparing ruxolitinib with either HydRoxycarbamIDe or interferon Alpha as first line ThErapy for high risk polycythemia vera.

Principal Investigator (PI): Dr Sylvia Feyler

Lung

IMReal: A non-interventional, multicentre, multi cohort study investigating the outcomes and safety of atezolizumab under real-world conditions in patients treated in routine clinical practice.

Principal Investigator (PI): Dr Nick Brown

SKYSCRAPER-03: A Phase III, open label, randomized study of Atezolizumab and Tiragolumab compared with Durvalumab in patients with locally advanced unrespectable stage III non-small cell lung cancer who have not progressed after concurrent platinum-based chemoradiation. 

Principal Investigator (PI): Dr Emma Rathbone

Prostate

STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy

Principal Investigator (PI): Dr Uschi Hofmann

Other Cancers

ACTICCA—1: Adjuvant chemotherapy with gemcitabine and cisplatin compared to standard of care after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial)

Principal Investigator (PI): Dr Emma Rathbone

ICI Genetics: Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity.  Participants recruited from all forms of cancer. 

Principal Investigator (PI): Dr Emma Rathbone

Other Specialty Research

Cardiovasular

EVAREST: The use of blood biomarkers, including Extracellular Vesicles, to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram.

Principal Investigator (PI): Dr Jeremy Butts

Gastrointestinal

PRED 4: Predicting serious drug side effects in gastroenterology.

Principal Investigator (PI): Dr Sunil Sonwalker

M20-256: A Phase 3, Multicenter, Randomized, Efficacy Assessor-Blinded Study of Risankizumab Compared to Ustekinumab for the Treatment of Adult Subjects With Moderate to Severe Crohn's Disease Who Have Failed Anti-TNF therapy.

Principal Investigator (PI): Dr Sunil Sonwalker

IBD BioResource: The UK Inflammatory Bowel Disease Bioresource: Progressing from Genetics to Function and Clinical Translation in Crohn's Disease & Ulcerative Colitis.

Principal Investigator (PI): Dr Sunil Sonwalker

Gynaecology & Obstetric

The BIG BABY Trial: Induction of labour for predicted macrosomia.

Principal Investigator (PI): Dr Julie Goddard

TTTS Registry: A physician-run Multiple Pregnancy Registry in collaboration with the Twin & Multiple Births Association (TAMBA), designed to serve the interests of patients while overcoming challenges of sharing data over great distances while protecting patient privacy.

Principal Investigator (PI): Dr Fifydani Shamsudin

AZTEC: Azithromycin Therapy for Chronic Lung Disease of Prematurity.

Principal Investigator (PI): Dr Gill Sharpe

AZTEC-2: Long term follow-up of Azithromycin Therapy for Chronic Lung Disease of Prematurity.

Prinicipal Investigator (PI): Dr Gill Sharpe

OASI2: Evaluation of strategies for care bundle implentation. 

Principal Investigator (PI): Midwife Rachel Clifford & Dr Ranadeb Acharyya

The CERM Trial: Chronic Endometritis and Recurrent Miscarriage.

Principal Investigator (PI): Dr Aris Makis 

CRAFT: Cerclarge after full dilatation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies.

Principal Investigator (PI): Dr Tahira Naeem

Protocol 7.0

Health Service & Delivery Research

FALLS: Practices of falls risk assessment and prevention in acute hospital settings: A realist investigation.

Principal Investigator (PI): Dr Abhijit Chakraborty

PQIP Perioperative Quality Improvement Programme: A patient study improving perioperative care through the use of quality data. Gathering and analysis of patient data using the PQIP Database. 

Principal Investigator (PI): Dr Alex Spyridoulias

Safety & patient Impact of AI Command Centre: Evaluating the safety and patient impact of an Artificial Intelligence Command Centre in the UK National Health Service (control site). 

Principal Investigator (PI): Jo Fawcus, Chief Operations Officer.

Hepatology

PBC Genetics Study: Investigation of the Genetic and Molecular Pathogenesis of Primary Biliary Cirrhosis.

rincipal Investigator (PI): Dr Susan Jones

UK-PSC: A UK Collaborative Study to Determine the Genetic Basis of Primary Sclerosing Cholangitis (UK-PSC).

Principal Investigator (PI): Dr Susan Jones

Infection

DexEnceph: A pragmatic, randomised, controlled, observer blind trial comparing clinical outcomes in adults who receive dexamethasone alongside standard treatment versus standard treatment alone for Herpes Simplex Virus encephalitis.

Principal Investigator (PI): Dr Rangaprasad Karadi

DEVA: Dequalinium versus usual care antibiotics for the treatment of bacterial vaginosis.  A multicentre randomised, open label, non-inferiority trial.

Principal Investigator (PI): Dr Emma Street

Midwifery

TTTS REGISTRY: Multiple Pregnancy Registry

Principal Investigator (PI): Dr Fifydani Shamsudin

CRAFT: CeRclage After Full dilaTation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies.

Principal Investigator (PI): Dr Tahira Naeem

Musculoskeletal

BSRBR: Toxicity from biologic therapy

Principal Investigator (PI): Dr Omer Sharif 

INSPIRE: INjectable treatments for patients with Shoulder Pain: a prospective observatIonal study to deteRmine Efficacy: Does injection treatment improve 26-week shoulder symptoms? A multi-centre, observational, prospective study.

Principal Investigator (PI): Dr Rajesh Menon

ARTISAN: Acute Rehabilitation following Traumatic anterior shoulder dislocation.

Principal Investigator (PI): Dr Simon Fogerty

PRoCuRe - Partial Rotator Cuff Tear Repair Trial. The clinical and cost effectiveness of surgical repair of partial rotator cuff tears in patients with subacromial shoulder pain: A comparison of surgical repair versus surgery with no repair.  

Prinicpal Investigator (PI): Dr Simon Fogerty

Adherence to Shoulder rehab: Exploration of barriers and enablers to shoulder rehabilitation exercises.

Physiotherapist collaborators: Tash Maher & Laura Hedley 

Neurological

Validation of translational biomarkers of neuropathic pain: RECRUITMENT SUSPENDED The Identification and validation of translational biomarkers of Neuropathic Pain.  A matched cohort study investigating biomarkers in several sub-group populations of Neuropathic Pain.

Principal Investigator (PI): Dr Rajesh Menon

MIDI: Deep Learning for Identification of Abnormalities on Head MRI.

Principal Investigator (PI): Mrs Georgina Turner

Ophthalmology

EYE NEON - Prevalence of subclinical Non-Exudative choroidal neovascularisation and its contribution to prediction of exudatiON in fellow eyes with unilateral exudative AMD.

Principal Investigator (PI): Dr Indra Dias

GALE: A Phase 3 open-label, multicenter, extension study to evaluate the long-term safety and efficacy of pegcetacoplan in subjects with geographic atrophy secondary to age-related macular degeneration.

Principal Investigator (PI): Dr Indra Dias

GRIP Glaucoma Risk Prediction in ocular hypertension: a cohort study using electronic medical records to validate a risk predictor and determine the cost-effectiveness of different monitoring schemes according to risk of conversion to glaucoma.

Principal Investigator (PI): Dr Omar Rafiq

SEARCH: Visual scanning training for hemianopia. 

Principal Investigator (PI): Rachael Calvey

Paediatric

BIOJUME: Biology of Juvenile Myoclonic Epilepsy

Principal Investigator (PI): Dr Matthew Taylor

Cleft Collective: Cohort Studies - a large DNA backed prospective resource for the study of the genetic and environmental determinants of cleft lip and/or palate and the long term outcomes in children with cleft lip and/or palate.

Principal Investigator (PI): Mr Matthew Robinson

Cystic Fibrosis: Cystic Fibrosis Registry.

Principal Investigator (PI): Dr Amal Elnour

Rolandic Epilepsy Genomewide Association International Study (REGAIN): The study’s goal is to find the genetic basis for susceptibility to seizures and associated comorbidities for RE (Rolandic Epilepsy) using genomewide association approaches.

Principal Investigator (PI): Dr Matthew Taylor

CASAP Children's Acute Surgical Abdomen Programme: A study reviewing the type and quality of care provided to children undergoing emergency abdominal surgery in the UK. 

Principal Investigator (PI): Dr Stephen Hill

AZTEC Azithromycin Therapy for Chronic Lung Disease of Prematurity: A randomised, placebo controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants.

Principal Investigator (PI): Dr Gill Sharpe

CF START: The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF

Principal Investigator (PI): Dr Abdul Mattara

FEED1 - Fluids Exclusively Enteral from Day 1:  A randomised controlled trial of full milk feeds versus intravenous fluids with gradual feeding for preterm infants (30-33 weeks gestational age).

Principal Investigator (PI): Dr Abdul Mattara

SINEPOST: Checking development of babies exposed to Coronavirus infection at birth and comparing with development of babies not infected with coronavirus at birth to assess if there are lasting effects.

Principal Investigator (PI): Mrs Georgina Turner

Renal & Urogenital

RADAR: National Studies of Rare Kidney Diseases

Principal Investigator (PI): Dr Rahul Vundru

Respiratory

EMBARC: European Bronchiectasis Registry

Principal Investigator (PI): Dr Rehan Naseer

BTS Registry:  RECRUITMENT SUSPENDED Obesity related severe asthma – relationship between body mass index and symptoms, healthcare utilisation, demographics, medications, blood test results and lung function.

Principal Investigator (PI): Dr Rehan Naseer

TIPAL: The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole: a randomised placebo-controlled multi-centre clinical trial.

Principal Investigator (PI): Dr Anneka Biswas

Skin

BADBIR: British Association of Dermatologists Biologics and Immunomodulators Register

Principal Investigator (PI): Dr Corrine Jakeman

Stroke

PRECIOUS: Prevention of Complications to Improve Outcome in elderly patients with acute Stroke. A randomised, open, phase III, clinical trial with blinded outcome assessment

Principal Investigator (PI): Dr Pretap Rana

OPTIMAS: A randomised, controlled trial considering Optimal Timing of Anticoagulation after an acute ischaemic stroke.

Principal Investigator (PI): Dr Manohar Kini

ENRICH-AF: EdoxabaN foR IntraCranial Haemorrhage survivors with atrial fibrillation.

Principal Investigator (PI): Dr Pratap Rana 

Surgical

SUNFLOWER: A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones.

Principal Investigator (PI): Mr Arin Saha

ROSSINI: Reduction Of Surgical Site Infection using several Novel Interventions.

Principal Investigator (PI): Dr Muneer Junejo

SOFFT:  Suture fixation versus tension band wiring for simple olecranon fracture fixation: a multi-centre randomised controlled trial (Simple Olecranon Fracture Fixation Trial – SOFFT).

Principal Investigator (PI): Mr Neil Pennington

Trauma & Orthopaedics

PROFHER2: A three-arm randomised controlled trial to assess the effectiveness and cost-effectiveness of reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical care for acute three and four part fractures of the proximal humerus in patients over 65yrs of age - Proximal Fracture Of the Humerus: Evaluation by Randomisation trial No. 2.

Principal Investigator (PI): Mr Neil Pennington