Current Research

YCRBCIP: Yorkshire Cancer Research Bowel Cancer Improvement Programme. Does intensive multidisciplinary team intervention improve bowel cancer outcomes in Yorkshire?

Principal Investigator (PI): Ms Paula Pickersgill 

VODECA: This case controlled study is aiming to investigate Volatile Organic Compounds (VOCs) associated with adenomas and early colorectal cancer (CRC) ultimately developing a panel of VOCs that can be used to select patients for colonoscopy to improve detection of colorectal neoplasia and reduce deaths from colon cancer.

Principal Investigator (PI): Ms Tracy Wood

OnCoRe: Oncological Outcomes after Clinical Complete Response (cCR) in patients with rectal cancer.

Principal Investigator (PI): Miss Tamsyn Grey

AMPHI-EPI: AREG, EREG and EGFR: response to anti-EGFR agents in colorectal cancer

Principal Investigator (PI): Dr Nick Brown

RANGO: Rare Neoplasms of Gynaecological Origin A study of specified rare gynaecological cancers to facilitate in-depth analysis of their clinical and biological behaviours leading to a greater understanding of mechanisms of disease progression and response to treatment, possibly also applicable to common tumours.

Principal Investigator (PI): Dr Deivasikamani Ramanujam

CML Registry: The study programme to investigate modern trends in Chronic Myeloid Leukemia (CML)

Principal Investigator (PI): Dr Kate Rothwell

FLAIR: This is a phase III, multicentre, randomised, controlled, open, parallel group trial in patients with previously untreated CLL.

Principal Investigator (PI): Dr Kate Rothwell

MDS Registry for newly diagnosed patients: A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes

Principal Investigator (PI): Dr Kate Rothwell

Myeloma XII (ACCoRd trial) Version 1.0: A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT Consolidation and maintenance strategy in patients with Relapsed multiple myeloma.

Principal Investigator (PI): Dr Sylvia Feyler

MYELOMA XIV (FITNESS): A phase III trial to compare standard and frailty-adjusted induction therapy with ixazomib, lenalidomide and dexamethasone (IRD) and maintenance lenalidomide (R) to lenalidomide plus ixazomib (R+I)

Principal Investigator (PI): Dr Sylvia Feyler

RADAR (UK-MRA Myeloma XV): Risk-Adapted therapy Directed According to Response comparing treatment escalation and de-escalation strategies in newly diagnosed patients with multiple myeloma (NDMM) suitable for stem cell transplant (TE).

Principal Investigator (PI): Dr Sylvia Feyler

MIRTHRIDATE: A phase III, randomised, open-label, Multicenter International Trial comparing ruxolitinib with either HydRoxycarbamIDe or interferon Alpha as first line ThErapy for high risk polycythemia vera.

Principal Investigator (PI): Dr Sylvia Feyler

STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy

Principal Investigator (PI): Dr Uschi Hofmann

ACTICCA—1: Adjuvant chemotherapy with gemcitabine and cisplatin compared to standard of care after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial)

Principal Investigator (PI): Dr Emma Rathbone

ICI Genetics: Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity.  Participants recruited from all forms of cancer. 

Principal Investigator (PI): Dr Emma Rathbone

PRED 4: Predicting serious drug side effects in gastroenterology.

Principal Investigator (PI): Dr Sunil Sonwalker

The BIG BABY Trial: Induction of labour for predicted macrosomia.

Principal Investigator (PI): Dr Julie Goddard

OASI2: A hybrid effectiveness implementation RCT to inform scale up of care bundle to reduce obstetric anal sphincter injury (OASI) caused during childbirth.

Principal Investigator (PI): Dr Anadeb Acharyya

DexEnceph: A pragmatic, randomised, controlled, observer blind trial comparing clinical outcomes in adults who receive dexamethasone alongside standard treatment versus standard treatment alone for Herpes Simplex Virus encephalitis.

Principal Investigator (PI): Dr Rangaprasad Karadi

DEVA: Dequalinium versus usual care antibiotics for the treatment of bacterial vaginosis.  A multicentre randomised, open label, non-inferiority trial.

Principal Investigator (PI): Dr Emma Street

TTTS REGISTRY: Multiple Pregnancy Registry

Principal Investigator (PI): Dr Fifydani Shamsudin

CRAFT: CeRclage After Full dilaTation caesarean section; an investigation into the role of previous in labour caesarean section in future preterm birth risk and potential management strategies.

Principal Investigator (PI): Dr Tahira Naeem

Migrant Women’s Experiences of Maternity Care Within the NHS, Phase 2.

Principal Investigator (PI): Dr Gweneth Lonergan

RETHINK: A study to determine if pregnant women who pain catastrophise are more likely to attend hospital during the latent phase of labour.

Principal Investigator (PI): Mr David Bromley 

BSRBR: Toxicity from biologic therapy

Principal Investigator (PI): Dr Omer Sharif 

ARTISAN: Acute Rehabilitation following Traumatic anterior shoulder dislocation.

Principal Investigator (PI): Dr Simon Fogerty

PRoCuRe - Partial Rotator Cuff Tear Repair Trial. The clinical and cost effectiveness of surgical repair of partial rotator cuff tears in patients with subacromial shoulder pain: A comparison of surgical repair versus surgery with no repair.  

Prinicpal Investigator (PI): Dr Simon Fogerty

Validation of translational biomarkers of neuropathic pain: RECRUITMENT SUSPENDED The Identification and validation of translational biomarkers of Neuropathic Pain.  A matched cohort study investigating biomarkers in several sub-group populations of Neuropathic Pain.

Principal Investigator (PI): Dr Rajesh Menon

MIDI: Deep Learning for Identification of Abnormalities on Head MRI.

Principal Investigator (PI): Mrs Georgina Turner

EYE NEON - Prevalence of subclinical Non-Exudative choroidal neovascularisation and its contribution to prediction of exudatiON in fellow eyes with unilateral exudative AMD.

Principal Investigator (PI): Dr Indra Dias

GALE - Phase 3 open-label, multicenter, extension study to evaluate the longterm safety and efficacy of pegcetacoplan in subjects with geographic atrophy secondary to age-related macular degeneration.

Principal Investigator (PI) Dr Indra Dias

GRIP Glaucoma Risk Prediction in ocular hypertension - A cohort study using electronic medical records to validate a risk predictor and determine the cost-effectiveness of different monitoring schemes according to risk of conversion to glaucoma.

Principal Investigator (PI): Dr Omar Rafiq

BIOJUME: Biology of Juvenile Myoclonic Epilepsy

Principal Investigator (PI): Dr Matthew Taylor

Cleft Collective: Cohort Studies - a large DNA backed prospective resource for the study of the genetic and environmental determinants of cleft lip and/or palate and the long term outcomes in children with cleft lip and/or palate.

Principal Investigator (PI): Mr Matthew Robinson

Cystic Fibrosis: Cystic Fibrosis Registry.

Principal Investigator (PI): Dr Amal Elnour

FADES: Feeding and Autoimmunity in Down's syndrome Evaluation Study.

Principal Investigator (PI): Dr Venkat Thiyagesh

Rolandic Epilepsy Genomewide Association International Study (REGAIN): The study’s goal is to find the genetic basis for susceptibility to seizures and associated comorbidities for RE (Rolandic Epilepsy) using genomewide association approaches.

Principal Investigator (PI): Dr Matthew Taylor

CASAP Children's Acute Surgical Abdomen Programme: A study reviewing the type and quality of care provided to children undergoing emergency abdominal surgery in the UK. 

Principal Investigator (PI): Dr Stephen Hill

AZTEC Azithromycin Therapy for Chronic Lung Disease of Prematurity: A randomised, placebo controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants.

Principal Investigator (PI): Dr Gill Sharpe

CF START: The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF

Principal Investigator (PI): Dr Abdul Mattara

ORION-4: Assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease.

Principal Investigator (PI): Dr Karen Mitchell

RADAR: National Studies of Rare Kidney Diseases

Principal Investigator (PI): Dr Rahul Vundru

EMBARC: European Bronchiectasis Registry

Principal Investigator (PI): Dr Rehan Naseer

BTS Registry:  RECRUITMENT SUSPENDED Obesity related severe asthma – relationship between body mass index and symptoms, healthcare utilisation, demographics, medications, blood test results and lung function.

Principal Investigator (PI): Dr Rehan Naseer

TIPAL: The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole: a randomised placebo-controlled multi-centre clinical trial.

Principal Investigator (PI): Dr Anneka Biswas

BADBIR: British Association of Dermatologists Biologics and Immunomodulators Register

Principal Investigator (PI): Dr Corrine Jakeman

PRECIOUS: Prevention of Complications to Improve Outcome in elderly patients with acute Stroke. A randomised, open, phase III, clinical trial with blinded outcome assessment

Principal Investigator (PI): Dr Anand Nair

OPTIMAS: A randomised, controlled trial considering Optimal Timing of Anticoagulation after an acute ischaemic stroke.

Principal Investigator (PI): Dr Anand Nair

ENRICH-AF: EdoxabaN foR IntraCranial Haemorrhage survivors with atrial fibrillation.

Principal Investigator (PI): Dr Pratap Rana 

SUNFLOWER: A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones.

Principal Investigator (PI): Mr Arin Saha

ROSSINI: Reduction Of Surgical Site Infection using several Novel Interventions.

Principal Investigator (PI): Dr Muneer Junejo

PROFHER2: A three-arm randomised controlled trial to assess the effectiveness and cost-effectiveness of reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical care for acute three and four part fractures of the proximal humerus in patients over 65yrs of age - Proximal Fracture Of the Humerus: Evaluation by Randomisation trial No. 2.

Principal Investigator (PI): Mr Neil Pennington

SOFFT:Simple Olecranon Fracture Fixation Trial. Suture fixation versus tension band wiring for simple olecranon fracture fixation: a multi-centre randomised controlled trial.

Prinicipal Investigator (PI): Mr Neil Pennington