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Current Research

The types of research currently undertaken at the Trust are varied, from complex clinical trials, qualitative health service research, registries, post-marketing surveillance to trainee doctors and students doing low risk, own account studies. Much of this research has been adopted by the National Institute of Health Research (approx 90%) with a small number of commercial/pharmaceutical (independent of NIHR) making up the rest.

Please view the sections below to look at the current research activity at Calderdale & Huddersfield Foundation Trust by Specialty.

Cancer

Breast

ROSCO: Response to Optimal Selection of neo-adjuvant Chemotherapy in Operable breast cancer: A randomised phase III, stratified biomarker trial of neo­adjuvant 5-Fluorouracil, Epirubicin and Cyclophosphamide vs Docetaxel and Cyclophosphamide chemotherapy.

Principal Investigator (PI): Professor Johnathan Joffe

UNIRAD: Randomized, double-blind, multicentre phase III trial evaluating the safety and benefit of adding everolimus to adjuvant hormone therapy in women with poor prognosis, ER+ and HER2- primary breast cancer who remain free of disease after receiving at least 1 year of adjuvant hormone therapy.

Principal Investigator (PI): Professor Johnathan Joffe

ONCOTYPE DX: The impact of the Oncotype DX Breast Cancer Assay on treatment decisions in a UK population of patients with Estrogen Receptor-Positive Early Breast Cancer with 1-3 Positive Lymph Nodes, who are potential candidates for chemotherapy, but for whom the benefits of chemotherapy are uncertain.

Principal Investigator (PI): Dr Jo Dent

PRIMETIME: Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers.

Principal Investigator (PI): Mr Neil Roberts

E-PATH: Randomised controlled trial of an app-based digital intervention to support breast cancer survivorsprescribed hormone therapy. 

Principal Investigator (PI): Ms Joyce Graham

Colorectal

FOCUS 4: Molecular selection of therapy in colorectal cancer: a molecularly stratified randomised controlled trials programme.

Principal Investigator (PI): Dr Jo Dent

YCRBCIP: Yorkshire Cancer Research Bowel Cancer Improvement Programme. Does intensive multidisciplinary team intervention improve bowel cancer outcomes in Yorkshire?

Principal Investigator (PI): Ms Paula Pickersgill 

VODECA: This case controlled study is aiming to investigate Volatile Organic Compounds (VOCs) associated with adenomas and early colorectal cancer (CRC) ultimately developing a panel of VOCs that can be used to select patients for colonoscopy to improve detection of colorectal neoplasia and reduce deaths from colon cancer.

Principal Investigator (PI): Ms Tracy Wood

Gynaecological

ICON8 & ICON8B Trial Programme:  ICON8 - An international phase III randomised trial of dose-fractionated chemotherapy compared to standard three-weekly chemotherapy, following immediate primary surgery or as part of delayed primary surgery, for women with newly diagnosed epithelial ovarian, fallopian tube or primary peritoneal cancer and ICON8B - A phase III randomised trial investigating the combination of dose-fractionated chemotherapy & bevacizumab compared to either strategy alone for the first line treatment of women with newly diagnosed high risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer.

Principal Investigator (PI): Dr Uschi Hofmann

Haematology

CML Registry: the study programme to investigate modern trends in Chronic Myeloid Leukemia (CML)

Principal Investigator (PI): Dr Kate Rothwell

FLAIR: This is a phase III, multicentre, randomised, controlled, open, parallel group trial in patients with previously untreated CLL.

Principal Investigator (PI): Dr Kate Rothwell

MDS Registry for newly diagnosed patients: A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes

Principal Investigator (PI): Dr Sylvia Feyler

Myeloma XII (ACCoRd trial) Version 1.0: A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT Consolidation and maintenance strategy in patients with Relapsed multiple myeloma.

Principal Investigator (PI): Dr Srivasavi Dukka

Lung

LungCAST: Does smoking status after a diagnosis of lung cancer affect outcomes?

Principal Investigator (PI): Dr Emma Rathbone

Lymphoma

MaPLe: Molecular profiling for lymphoma; to permit prospective molecular typing of samples of non-Hodgkin lymphoma from surplus material obtained at routine biopsies.

Principal Investigator (PI): Dr Kate Rothwell

Other Cancers

Life and Bladder Cancer: The Yorkshire Cancer Research Bladder Cancer Patient Reported Outcomes Survey

Principal Investigator (PI):  Mr Nicholas Bryan

ePRIME Yorkshire: electronic Patient self-Reported outcomes to Improve cancer Management and patient Experiences: Remote monitoring of cancer patients in remission

Principal Investigator (PI): Dr Uschi Hofmann

 

Prostrate

PATCH: Prostate Adenocarcinoma: TransCutaneous Hormones. A randomised-controlled trial of transcutaneous oestrogen patches versus LHRH analogues in prostate cancer.

Principal Investigator (PI): Dr Uschi Hofmann

STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy

Principal Investigator (PI): Dr Uschi Hofmann

Upper Gastrointestinal

Add-Aspirin Trial (UGI): A phase III, double blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours.

Principal Investigator (PI): Professor Johnathan Joffe

Cardiovasular

UKGRIS: Effectiveness of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome.

Principal Investigator (PI): Dr Jeremy Butts

EVAREST: The use of blood biomarkers, including Extracellular Vesicles, to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram.

Principal Investigator (PI): Dr Jeremy Butts

CONNECT: The development, acceptability and usability of an interactive digital patient decision tool for elective coronary angioplasty.

Principal Investigator (PI): Dr Jeremy Butts

 

 

Diabetes

DRN 818 MY DIABETES: A cross-sectional study to characterise young-onset diabetes in two UK ethnic groups.

Principal Investigator (PI): Dr Stephanie How Yaw

MIDFUT: Multiple Interventions for Diabetic Foot Ulcer Treatment Trial.

Principal Investigator (PI): Ms Jane Findlater

SleepT2D: The impact of Sleep Disorders in Patients with Type 2 Diabetes: A Cohort Study and Feasibility RCT

Principal Investigator (PI):  Dr Julie Kyaw-Tun

Gastrointestinal

PRED 4: Predicting Serious Drug Side Effects in Gastroenterology.

Principal Investigator (PI): Dr Sunil Sonwalker

Gynaecology & Obstetric

VIP Study: Decision making during childbirth; Interactional practices of decision making during childbirth in maternity units.

Principal Investigator (PI): Dr Tomasina Stacey

The Future Study: Female Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study); a superiority randomised clinical trial to evaluate the effectiveness and cost effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms.

Principal Investigator (PI): Dr Yi-Ling Chan

C-STICH: Cerclage Suture Type for an Insufficient Cervix and its effect on Health Outcomes.

Principal Investigator (PI): Dr Tahira Naeem

The BIG BABY Trial: Induction of labour for predicted macrosomia.

Principal Investigator (PI): Dr Julie Goddard

Amb Transf Labour: A qualitative study into exploration of ambulance transfer of labouring women to an obstetric unit where birth is planned at home or in a free-standing midwifery unit (FMU).

Principal Investigator (PI): Mrs Sue Townend

Infection

PrEP Impact Trial: A pragmatic health technology assessment of PREP and implementation. To test the hypothesis that consensus estimates using best available data on PrEP need, uptake and duration of use are correct and, if not, provide accurate measures across the complexity of the population likely to benefit from this medicinal product.

Principal Investigator (PI): Dr Maneh Farazmand

DexEnceph: A pragmatic, randomised, controlled, observer blind trial comparing clinical outcomes in adults who receive dexamethasone alongside standard treatment versus standard  treatment alone for Herpes Simplex Virus encephalitis.

Principal Investigator (PI): Dr Rangaprasad Karadi

Neurological

Validation of translational biomarkers of neuropathic pain: The Identification and validation of translational biomarkers of Neuropathic Pain.  A matched cohort study investigating biomarkers in several sub-group populations of Neuropathic Pain.

Principal Investigator (PI): Dr Rajesh Menon

Musculoskeletal

ARTISAN: Acute Rehabilitation following Traumatic anterior shoulder dislocation.

Principal Investigator (PI): Dr Simon Fogerty

Hepatology

PBC Genetics Study: Investigation of the Genetic and Molecular Pathogenesis of Primary Biliary Cirrhosis.

Principal Investigator (PI): Dr Susan Jones

UK-PSC: A UK Collaborative Study to Determine the Genetic Basis of Primary Sclerosing Cholangitis (UK-PSC).

Principal Investigator (PI): Dr Susan Jones

Ophthalmology

StereoTactic radiotherapy for wet Age-Related macular degeneration (STAR): A randomised, double-masked, sham-controlled, clinical trial comparing low-voltage X-ray irradiation with as needed ranibizumab, to as needed ranibizumab monotherapy.

Principal Investigator (PI): Dr Indra Dias

Paediatric

BIOJUME: Biology of Juvenile Myoclonic Epilepsy

Principal Investigator (PI): Dr Matthew Taylor

The BOSS Study: The British Orthopaedic Surgery Surveillance Study: A nationwide service evaluation, and nested-cohort study.

Principal Investigator (PI): Mr Nitish Gogi

CHIPS+: Optimising the health of young people with HIV in their transition from paediatric to adult care.

Principal Investigator (PI): Ms Lindsay Short

DRN100 (TrialNet): TrialNet Natural History Study of the Development of Type 1 Diabetes. Phase 1,2 and 3.

Principal Investigator (PI): Dr Lynne Terrett

Genetic determinants of Kawasaki disease: The aim of the study is to identify the genes underlying susceptibility to Kawasaki Disease, and also underlying differing sequelae of the disease such as coronary artery aneurysms.

Principal Investigator (PI): Dr Khaleel-Ur Rahman 

Cleft Collective: Cohort Studies - a large DNA backed prospective resource for the study of the genetic and environmental determinants of cleft lip and/or palate and the long term outcomes in children with cleft lip and/or palate.

Principal Investigator (PI): Ms Marie Home

Cystic Fibrosis: Cystic Fibrosis Registry.

Principal Investigator (PI): Dr Jonathan Garside

ASD UK: An Epidemiological ASD Study and Establishing a Research Database.

Principal Investigator (PI): Dr Alistair Morris

FADES: Feeding and Autoimmunity in Down's syndrome Evaluation Study.

Principal Investigator (PI): Dr Venkat Thiyagesh

REGAIN Rolandic Epilepsy Genomewide Association International Study:   the study’s goal is to find the genetic basis for susceptibility to seizures and associated comorbidities for RE (Rolandic Epilepsy) using genomewide association approaches.

Principal Investigator (PI): Dr Matthew Taylor

PEACHY: PErioperAtive CHildhood obesity or PEACHY is a prospective observational cohort study investigating the proportion of overweight and obese children presenting for a procedure under general anaesthesia in the UK and the incidence of preoperative adverse outcomes in this patient group.

Principal Investigator (PI): Dr Karen Bartholomew

Respiratory

EMBARC:  European Bronchiectasis Registry

Principal Investigator (PI): Dr Rehan Naseer

SCOPE:  Study of etC02 in the diagnosis of pulmonary embolism.  This research hopes to prove that a simple bedside breath test can diagnose a blood clot on the lungs, helping patients avoid unnecessary blood tests and exposure to radiation from CT Scans.

Principal Investigator (PI): Dr  Jonathan Walker

Renal & Urogenital

RADAR:  National Studies of Rare Kidney Diseases

Principal Investigator (PI): Dr Mansoor Ali

Stroke

Stroke InvestiGation Network- Understanding Mechanisms (SIGNUM):  Determinants of prognosis in stroke?  

Principal Investigator (PI): Dr Anand Nair

PRECIOUS: Prevention of Complications to Improve Outcome in elderly patients with acute Stroke. A randomised, open, phase III, clinical trial with blinded outcome assessment

Principal Investigator (PI): Dr Anand Nair

SoSTART: Start or Stop Anticoagulants

Principal Investigator (PI): Dr Anand Nair

TRIDENT: Triple therapy prevention of Recurrent Intracerebral Disease Events Trial

Principal Investigator (PI): Dr Manohar Kini 

TWIST: A randomised-controlled trial of thrombolytic treatment with tenecteplase for acute ischaemic stroke upon awakening. 

Principal Investigator (PI): Dr Anand Nair

LACI-2: LACunar Intervention (LACI-2) Trial-2: Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to prevent recurrent lacunar stroke and progression of cerebral small vessel disease. 

Principal Investigator (PI): Dr Pratap Rana

Talking about recovery after stroke:  A qualitative study of current practice and exploration of the views of stroke survivors, caregivers and staff.

Principal Investigator (PI):  Dr Louisa-Jane Burton

Sexual Health

HIV Stigma: The People Living with HIV Stigma Survey UK

Principal Investigator (PI): Dr Maneh Farazmand

Surgical

PROFHER2: A three-arm randomised controlled trial to assess the effectiveness and cost-effectiveness of reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical care for acute three and four part fractures of the proximal humerus in patients over 65yrs of age - Proximal Fracture Of the Humerus: Evaluation by Randomisation trial No. 2.

Principal Investigator (PI): Mr Neil Pennington

SUNFLOWER: A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones.

Principal Investigator (PI): Mr Arin Saha

CIPHER: A UK Cohort study to investigate the prevention of Parastomal Hernia.

Principal Investigator (PI): Mr Jonathan Cowley

PPAC2: Packing of Perianal Abscess Cavities 2.  A multicentre randomised controlled study to assess the impact of postoperative packing of Perianal Abscess Cavities.

Principal Investigator (PI): Miss Tamsyn Grey