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Current Research

The types of research currently undertaken at the Trust are varied, from complex clinical trials, qualitative health service research, registries, post-marketing surveillance to trainee doctors and students doing low risk, own account studies. Much of this research has been adopted by the National Institute of Health Research (approx 90%) with a small number of commercial/pharmaceutical (independent of NIHR) making up the rest.

Due to the current COVID-19 outbreak Calderdale & Huddersfield NHS Foundation Trust have suspended recruitment on a number of their studies. 

Please view the sections below giving status for each research study at Calderdale & Huddersfield Foundation Trust.

Cancer Research

ROSCO: OPEN Response to Optimal Selection of neo-adjuvant Chemotherapy in Operable breast cancer: A randomised phase III, stratified biomarker trial of neo­adjuvant 5-Fluorouracil, Epirubicin and Cyclophosphamide vs Docetaxel and Cyclophphamide chemotherapy.

Principal Investigator (PI): Dr Jo Dent

ONCOTYPE DX: OPEN  The impact of the Oncotype DX Breast Cancer Assay on treatment decisions in a UK population of patients with Estrogen Receptor-Positive Early Breast Cancer with 1-3 Positive Lymph Nodes, who are potential candidates for chemotherapy, but for whom the benefits of chemotherapy are uncertain.

Principal Investigator (PI): Dr Jo Dent

PRIMETIME: OPEN Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers.

Principal Investigator (PI): Mr Neil Roberts

YCRBCIP: OPEN Yorkshire Cancer Research Bowel Cancer Improvement Programme. Does intensive multidisciplinary team intervention improve bowel cancer outcomes in Yorkshire?

Principal Investigator (PI): Ms Paula Pickersgill 

VODECA: OPEN This case controlled study is aiming to investigate Volatile Organic Compounds (VOCs) associated with adenomas and early colorectal cancer (CRC) ultimately developing a panel of VOCs that can be used to select patients for colonoscopy to improve detection of colorectal neoplasia and reduce deaths from colon cancer.

Principal Investigator (PI): Ms Tracy Wood

OnCoRe: OPEN Oncological Outcomes after Clinical Complete Response (cCR) in patients with rectal cancer.

Principal Investigator (PI): Miss Tamsyn Grey

AMPHI-EPI: OPEN AREG, EREG and EGFR: response to anti-EGFR agents in colorectal cancer

Principal Investigator (PI): Dr Nick Brown

RANGO: RECRUITMENT SUSPENDED Rare Neoplasms of Gynaecological Origin A study of specified rare gynaecological cancers to facilitate in-depth analysis of their clinical and biological behaviours leading to a greater understanding of mechanisms of disease progression and response to treatment, possibly also applicable to common tumours.

Principal Investigator (PI): Dr Deivasikamani Ramanujam

CML Registry: OPEN The study programme to investigate modern trends in Chronic Myeloid Leukemia (CML)

Principal Investigator (PI): Dr Kate Rothwell

FLAIR: OPEN This is a phase III, multicentre, randomised, controlled, open, parallel group trial in patients with previously untreated CLL.

Principal Investigator (PI): Dr Kate Rothwell

MDS Registry for newly diagnosed patients: RECRUITMENT SUSPENDED  A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes

Principal Investigator (PI): Dr Kate Rothwell

Myeloma XII (ACCoRd trial) Version 1.0: OPEN A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT Consolidation and maintenance strategy in patients with Relapsed multiple myeloma.

Principal Investigator (PI): Dr Sylvia Feyler

MYELOMA XIV (FITNESS): OPEN A phase III trial to compare standard and frailty-adjusted induction therapy with ixazomib, lenalidomide and dexamethasone (IRD) and maintenance lenalidomide (R) to lenalidomide plus ixazomib (R+I)

Principal Investigator (PI): Dr Sylvia Feyler

LI-1: OPEN Phase II/III. A programme of development for older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome.

Principal Investigator (PI): Dr Kate Rothwell

MaPLe: OPEN Molecular profiling for lymphoma; to permit prospective molecular typing of samples of non-Hodgkin lymphoma from surplus material obtained at routine biopsies.

Principal Investigator (PI): Dr Kate Rothwell

STAMPEDE: RECRUITMENT SUSPENDED Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy

Principal Investigator (PI): Dr Uschi Hofmann

ACTICCA—1: OPEN Adjuvant chemotherapy with gemcitabine and cisplatin compared to standard of care after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial)

Principal Investigator (PI): Dr Emma Rathbone

Add-Aspirin Trial: OPEN A phase III, double blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours.

Principal Investigator (PI): Professor Johnathan Joffe

Other Specialty Research

EVAREST: RECRUITMENT SUSPENDED The use of blood biomarkers, including Extracellular Vesicles, to improve the diagnostic accuracy of cardiac assessment by stress echocardiogram.

Principal Investigator (PI): Dr Jeremy Butts

DRN 818 MY DIABETES: RECRUITMENT SUSPENDED A cross-sectional study to characterise young-onset diabetes in two UK ethnic groups.

Principal Investigator (PI): Dr Stephanie How Yaw

CUSP: OPEN Comparing outcomes for severely and profoundly deaf children

Principal Investigator (PI): Miss Carla Wallace

Predicting serious drug side effects in gastroenterology RECRUITMENT SUSPENDED

Principal Investigator (PI): Dr Sunil Sonwalker

The Future Study: OPEN Female Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study); a superiority randomised clinical trial to evaluate the effectiveness and cost effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms.

Principal Investigator (PI): Dr Yi-Ling Chan

C-STICH: OPEN Cerclage Suture Type for an Insufficient Cervix and its effect on Health Outcomes.

Principal Investigator (PI): Dr Tahira Naeem

The BIG BABY Trial: OPEN Induction of labour for predicted macrosomia.

Principal Investigator (PI): Dr Julie Goddard

PBC Genetics Study: OPEN Investigation of the Genetic and Molecular Pathogenesis of Primary Biliary Cirrhosis.

rincipal Investigator (PI): Dr Susan Jones

UK-PSC: RECRUITMENT SUSPENDED A UK Collaborative Study to Determine the Genetic Basis of Primary Sclerosing Cholangitis (UK-PSC).

Principal Investigator (PI): Dr Susan Jones

DexEnceph: OPEN A pragmatic, randomised, controlled, observer blind trial comparing clinical outcomes in adults who receive dexamethasone alongside standard treatment versus standard treatment alone for Herpes Simplex Virus encephalitis.

Principal Investigator (PI): Dr Rangaprasad Karadi

TTTS REGISTRY: OPEN Multiple Pregnancy Registry

Principal Investigator (PI): Dr Fifydani Shamsudin

Cerclage after full dilatation caesarean section: RECRUITMENT SUSPENDED

Principal Investigator (PI): Dr Tahira Naeem

BSRBR: RECRUITMENT SUSPENDED Toxicity from biologic therapy

Principal Investigator (PI): Dr Omer Sharif 

ARTISAN: RECRUITMENT SUSPENDED Acute Rehabilitation following Traumatic anterior shoulder dislocation.

Principal Investigator (PI): Dr Simon Fogerty

Validation of translational biomarkers of neuropathic pain: RECRUITMENT SUSPENDED The Identification and validation of translational biomarkers of Neuropathic Pain.  A matched cohort study investigating biomarkers in several sub-group populations of Neuropathic Pain.

Principal Investigator (PI): Dr Rajesh Menon

No current ophthalmology related studies

BIOJUME: OPEN Biology of Juvenile Myoclonic Epilepsy

Principal Investigator (PI): Dr Matthew Taylor

CHIPS+: OPEN Optimising the health of young people with HIV in their transition from paediatric to adult care.

Principal Investigator (PI): Ms Lindsay Short

Genetic determinants of Kawasaki disease: RECRUITMENT SUSPENDED The aim of the study is to identify the genes underlying susceptibility to Kawasaki Disease, and also underlying differing sequelae of the disease such as coronary artery aneurysms.

Principal Investigator (PI): Dr Khaleel-Ur Rahman  

Cleft Collective: RECRUITMENT SUSPENDED Cohort Studies - a large DNA backed prospective resource for the study of the genetic and environmental determinants of cleft lip and/or palate and the long term outcomes in children with cleft lip and/or palate.

Principal Investigator (PI): Ms Marie Home

Cystic Fibrosis: RECRUITMENT SUSPENDED Cystic Fibrosis Registry.

Principal Investigator (PI): Dr Amal Elnour

FADES: OPEN Feeding and Autoimmunity in Down's syndrome Evaluation Study.

Principal Investigator (PI): Dr Venkat Thiyagesh

Rolandic Epilepsy Genomewide Association International Study (REGAIN) OPEN The study’s goal is to find the genetic basis for susceptibility to seizures and associated comorbidities for RE (Rolandic Epilepsy) using genomewide association approaches.

Principal Investigator (PI): Dr Matthew Taylor

CASAP Children's Acute Surgical Abdomen Programme: OPEN  A study reviewing the type and quality of care provided to children undergoing emergency abdominal surgery in the UK.

Principal Investigator (PI): Dr Stephen Hill

PRECEPT Study (Prevention of cerebral palsy in pre-term labour): OPEN

Principal Investigator (PI): Dr Abdul Mattara

Azithromycin Therapy for Chronic Lung Disease of Prematurity: OPEN

Principal Investigator (PI): Dr Gill Sharpe

CF START: RECRUITMENT SUSPENDED The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF

Principal Investigator (PI): Dr Abdul Mattara

Baby-OSCAR Trial: CONTINUING CARE SITE Outcome after Selective Early Treatment for Closure of Patent Ductus ARteriosus in Preterm Babies

Principal Investigator (PI): Dr Eileen Crosbie

UKALL 2011: CONTINUING CARE SITE United Kingdom National Randomised Trial For Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011

Principal Investigator (PI): Dr Gill Sharpe

ORION-4: OPEN Assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease.

Principal Investigator (PI): Dr Karen Mitchell

RADAR:  RECRUITMENT SUSPENDED National Studies of Rare Kidney Diseases

Principal Investigator (PI): Dr Rahul Vundru

EMBARC: RECRUITMENT SUSPENDED European Bronchiectasis Registry

Principal Investigator (PI): Dr Rehan Naseer

BTS Registry: RECRUITMENT SUSPENDED Obesity related severe asthma – relationship between body mass index and symptoms, healthcare utilisation, demographics, medications, blood test results and lung function.

Principal Investigator (PI): Dr Rehan Naseer

No current sexual health related studies.

BADBIR: RECRUITMENT SUSPENDED British Association of Dermatologists Biologics and Immunomodulators Register

Principal Investigator (PI): Dr Corrine Jakeman

PRECIOUS: RECRUITMENT SUSPENDED Prevention of Complications to Improve Outcome in elderly patients with acute Stroke. A randomised, open, phase III, clinical trial with blinded outcome assessment

Principal Investigator (PI): Dr Anand Nair

TRIDENT: RECRUITMENT SUSPENDED Triple therapy prevention of Recurrent Intracerebral Disease Events Trial

Principal Investigator (PI): Dr Manohar Kini

LACI-2: RECRUITMENT SUSPENDED LACunar Intervention (LACI-2) Trial-2: Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to prevent recurrent lacunar stroke and progression of cerebral small vessel disease. 

Principal Investigator (PI): Dr Pratap Rana

OPTIMAS: OPEN A randomised, controlled trial considering Optimal Timing of Anticoagulation after an acute ischaemic stroke.

Principal Investigator (PI): Dr Anand Nair

SUNFLOWER: OPEN A randomised controlled trial to establish the clinical and cost effectiveness of expectant management versus pre-operative imaging with Magnetic Resonance Cholangiopancreatography (MRCP) in patients with symptomatic gallstones undergoing laparoscopic cholecystectomy at low or moderate risk of common bile duct stones.

Principal Investigator (PI): Mr Arin Saha

CIPHER: RECRUITMENT SUSPENDED A UK Cohort study to investigate the prevention of Parastomal Hernia.

Principal Investigator (PI): Mr Jonathan Cowley

ROSSINI: RECRUITMENT SUSPENDED Reduction Of Surgical Site Infection using several Novel Interventions.

Principal Investigator (PI): Dr Muneer Junejo

PROFHER2: OPEN A three-arm randomised controlled trial to assess the effectiveness and cost-effectiveness of reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical care for acute three and four part fractures of the proximal humerus in patients over 65yrs of age - Proximal Fracture Of the Humerus: Evaluation by Randomisation trial No. 2.

Principal Investigator (PI): Mr Neil Pennington